A physical basis for multi-fiber reconstruction from DW-MRI data
by Kumar, R. | Barmpoutis, A. | Vemuri, B. C. | Carney, P. | Mareci, T.
In Proceedings of ISBI09: IEEE International Symposium on Biomedical Imaging, June 28-July 1, 2009, pp. 626-629. https://doi.org/10.1109/ISBI.2009.5193125
In Proceedings of ISBI09: IEEE International Symposium on Biomedical Imaging, June 28-July 1, 2009, pp. 626-629. https://doi.org/10.1109/ISBI.2009.5193125
Description
Recently various mathematical models have been proposed to model the signal attenuation obtained from Diffusion Weighted Magnetic Resonance Imaging (DW-MRI). Though effective to various extents, almost all of the existing methods involve model parameters which are abstract mathematical quantities without any tangible connection to physical quantities (e.g. the b-value, gradient pulse duration, pulse separation etc.) involved in the DW-MRI acquisition process. To address this disconnect, in this paper, we present a multi-compartmental model which uses a physical model for restricted diffusion in the cylindrical geometry as the constituent basis function for multi-fiber reconstruction. Through extensive experiments on synthetic data we establish the superiority of the proposed method over the state-of-the-art techniques in terms of fiber orientation detection accuracy. We also present detailed results using human and rat brain data and demonstrate that our method leads to meaningful multi-fiber reconstruction even in the case of real data.
